Stephen Hauschka, PhD

Scientific Advisor

Steven Hauschka has been working on mechanisms of striated muscle development and gene regulation since 1963, with specific expertise stemming from many decades of at-the-bench muscle cell culture and muscle gene regulation research. His research lab at the University of Washington was the first to develop methods for clonal analysis of human skeletal muscle cells. They also discovered several of the growth factors and mechanisms related to myoblast growth & differentiation. As professor emeritus, he continues to do such studies on a daily basis in conjunction with current research focused on identifying skeletal and cardiac muscle gene enhancer and promoter regions, the control elements within these, and their relevant transcription factors. He has written several definitive methods reviews related to technical aspects of skeletal muscle culture, and has published technique papers related to transfection of muscle cultures and mice with AAV. Of particular note is Steve’s development of many different skeletal and cardiac Muscle-Specific Expression Cassettes (MSECs) that transcribe virtually any product in these cell types over a 3-log range. These MSECs are being used by a number of researchers and industry-leading gene therapy companies for muscle-specific CRISPR-mediated gene corrections and AAV-mediated gene transfer.  He is a co-founder of Kinea Bio.